Absci is a clinical-stage biopharmaceutical company headquartered in Vancouver, Washington that uses generative AI to design and develop differentiated drug therapeutics. Founded in 2011, Absci is publicly traded on Nasdaq (ABSI).

Caravel Bio is a Portland, Oregon–based synthetic biology startup building a novel protein evolution platform that creates proteins exceeding nature's bounds to serve as new protein machines. The company targets applications in critical minerals, carbon capture, and industrial processes using cell-free protein engineering methods.

Cascade Prodrug is an oncology-focused biotechnology company developing a novel class of hypoxia-activated prodrug therapies that target diseases rooted in oxygen deprivation, including solid tumors and wet AMD. Its lead program, CPD100, is designed to selectively activate in hypoxic tissue. The company is led by seasoned pharmaceutical and biotech executives.

ClearFlow, Inc. is a medical device company headquartered in Irvine, California, focused on post-surgical chest tube clearance. Its flagship product, the PleuraFlow Active Clearance Technology system, is designed to maintain chest tube patency following cardiac and thoracic surgery. The company holds a comprehensive portfolio of U.S. and international patents covering its clearance technology.

CytoImage is a Portland, Oregon-based biotechnology company founded in 2020 that develops imaging diagnostic technology for cancer detection. The company's platform provides rapid and precise assessment of phenotypic functional response to identify cancer cells, with its last known funding round in July 2021.

Célage Bioscience is a direct-to-consumer biotech skincare company based in Portland, OR, offering a clinically-advanced treatment system that combines growth factor-based skincare (C²+GF™ Complex using cytokine proteins) with at-home microneedling. The company was backed by Elevate VC. Crunchbase lists the company as permanently closed.

Hemex Health develops point-of-care blood diagnostic devices that help healthcare providers diagnose, monitor, and manage chronic diseases worldwide. The company focuses on commercializing cost-effective, intuitive diagnostic tools to make testing more accessible. Hemex Health is headquartered in Portland, Oregon, with an additional presence in Mumbai, India.

InVivo Biosystems is a biotechnology company headquartered in Eugene, Oregon, that delivers expertise and technology to accelerate therapeutic discovery. The company uses its proprietary platform to advance drug discovery for neurological, metabolic, and rare monogenic diseases.

KitoTech Medical is a medical device company that makes the microMend® family of wound closure products, offering a less painful and cost-effective alternative to traditional sutures and staples. The devices are designed for both personal use and healthcare professionals. In 2022, KitoTech entered a distribution agreement with Corza Medical to market microMend Pro in the US.

Madorra is a medical device company focused on women's health that has developed a therapeutic ultrasound device to treat vaginal atrophy in breast cancer survivors. The device increases vasodilation and blood flow to improve vaginal health and female sexual function, and originated from the Stanford Biodesign program.

Myoaligner is a dental technology company offering an FDA-cleared patented system for the treatment of migraine headaches, TMJ disorders (TMJD), tension headaches, and restorative dentistry applications. The device provides a non-invasive solution for patients suffering from temporomandibular joint disorders and related conditions.

Neurosom develops medical devices and therapeutic protocols to improve sleep through psychological training and neurotechnology. The company has created a noninvasive sleep therapy system designed for personalized sleep improvement.

Obatala Sciences is a life sciences company founded in 2017 dedicated to advancing drug development through human-derived organ-on-a-chip research solutions, with a focus on obesity, diabetes, and regenerative medicine. The company commercially launched its ObaCell Obesity-on-a-Chip service, providing researchers with physiologically relevant in vitro models.

Osheru is a medical device company specializing in minimally invasive technology for excess skin removal. Its flagship product, the Ziplyft, is an innovative sutureless compression device that streamlines eyelid (blepharoplasty) surgery. The company raised $4.7 million in funding in 2024 to advance the Ziplyft device.

Reperio Health is the world's only at-home health screening kit with instant results, removing common barriers to preventive care such as appointments and travel. The company delivers FDA-cleared, at-home diagnostic screenings with instant digital results and integrated virtual visits, focusing on claims-based preventive care for employers and health plans.

SavorEase (also styled Savorease) makes dissolvable, plant-based savory finger foods designed for people with dysphagia and chewing difficulties. Founded in 2015 by culinary chef and oral reconstruction specialist Dr. Reva Barewal, the company focuses on nutrition and dining enjoyment for adults and children on therapeutic or restricted diets.

SomnoSeal is a medical device company that makes a patient-friendly oral seal designed to help CPAP users who breathe through their mouths. The SomnoSeal device enables mouth breathers to comfortably use smaller nasal or nasal pillow style CPAP masks, which are generally better tolerated than full-face masks. It has been featured in dental sleep medicine publications as an effective solution for improving CPAP therapy compliance.

SurgiVance is a medical technology company developing advanced diagnostic imaging technologies using optics to bring rapid pathology diagnosis to the point of care. The company received a Phase II SBIR grant to commercialize its direct-to-digital pathology imaging platform and initiated a New York State-funded clinical pilot project.

SynPlexity is a biotech startup founded by University of Oregon professor Calin Plesa that commercializes DropSynth technology for scalable, parallel DNA synthesis. Its platform enables creation of multiplex gene libraries for applications in therapeutics, biomanufacturing, and agriculture, producing longer sequences at lower cost than competing technologies.

THAENA is a female-founded, Pacific Northwest-based science and wellness company developing novel microbiome-based therapies and supplements. The company produces what it describes as the world's first human-derived postbiotic supplement, featuring over 10,000 molecular signatures aimed at restoring microbiome signals. THAENA was founded with a mission to use science and radical innovation to improve human health and longevity.