Neurosom develops medical devices and therapeutic protocols to improve sleep through psychological training and neurotechnology. The company has created a noninvasive sleep therapy system designed for personalized sleep improvement.

Mickelberry Gardens is a women-owned certified B Corporation based in Portland, Oregon, founded by herbalist Madelyn and beekeeper Matt. The company offers a line of herbal wellness products inspired by honeybees, with a mission to provide healing and delicious products.

SurgiVance is a medical technology company developing advanced diagnostic imaging technologies using optics to bring rapid pathology diagnosis to the point of care. The company received a Phase II SBIR grant to commercialize its direct-to-digital pathology imaging platform and initiated a New York State-funded clinical pilot project.

Absci is a clinical-stage biopharmaceutical company headquartered in Vancouver, Washington that uses generative AI to design and develop differentiated drug therapeutics. Founded in 2011, Absci is publicly traded on Nasdaq (ABSI).

Acolyte Health is a patient engagement company that delivers personalized instructions, connections, and education to improve health outcomes. The company provides solutions that support patients through their care journey with tailored communications and resources.

Biomotum is a medical device company that builds wearable robotic rehabilitation products designed to support clinicians in improving walking function for individuals with neurologic impairments. Its Spark device is a powered exoskeleton intended for rehabilitation and personal use by individuals with gait impairments.

Bright.md was an asynchronous telehealth company whose platform allowed providers to treat low-acuity conditions virtually without requiring real-time interactions, enabling patients and providers to exchange messages and respond to clinical questions on their own schedule. Its assets were acquired by 98point6 in early 2024.

Bright.md is a telemedicine software company that automates clinical intake, workflows, and administrative tasks to improve care encounters through asynchronous and video telehealth. Its cloud-based platform enables providers and patients to exchange messages and respond to questions outside of real-time visits. In January 2024, 98point6 acquired Bright.md's assets to expand its asynchronous telehealth capabilities.

Caravel Bio is a Portland, Oregon–based synthetic biology startup building a novel protein evolution platform that creates proteins exceeding nature's bounds to serve as new protein machines. The company targets applications in critical minerals, carbon capture, and industrial processes using cell-free protein engineering methods.

Cascade Prodrug is an oncology-focused biotechnology company developing a novel class of hypoxia-activated prodrug therapies that target diseases rooted in oxygen deprivation, including solid tumors and wet AMD. Its lead program, CPD100, is designed to selectively activate in hypoxic tissue. The company is led by seasoned pharmaceutical and biotech executives.

ClearFlow, Inc. is a medical device company headquartered in Irvine, California, focused on post-surgical chest tube clearance. Its flagship product, the PleuraFlow Active Clearance Technology system, is designed to maintain chest tube patency following cardiac and thoracic surgery. The company holds a comprehensive portfolio of U.S. and international patents covering its clearance technology.

CytoImage is a Portland, Oregon-based biotechnology company founded in 2020 that develops imaging diagnostic technology for cancer detection. The company's platform provides rapid and precise assessment of phenotypic functional response to identify cancer cells, with its last known funding round in July 2021.

Célage Bioscience is a direct-to-consumer biotech skincare company based in Portland, OR, offering a clinically-advanced treatment system that combines growth factor-based skincare (C²+GF™ Complex using cytokine proteins) with at-home microneedling. The company was backed by Elevate VC. Crunchbase lists the company as permanently closed.

Deviceflow is an AI-native platform building a commercial operating system for medical device companies, automating operations such as order management, customer notifications, and ERP integrations. The company connects with accounting software and communication tools to streamline medical device sales and distribution workflows. Plug and Play Tech Center announced an investment in Deviceflow in April 2026.

Enable Sleep is a platform that helps dental practices offer oral appliance therapy for sleep apnea, connecting them with sleep physicians and supporting clinical documentation and workflows. The company serves as a bridge between dental providers and the sleep medicine ecosystem.

Hemex Health develops point-of-care blood diagnostic devices that help healthcare providers diagnose, monitor, and manage chronic diseases worldwide. The company focuses on commercializing cost-effective, intuitive diagnostic tools to make testing more accessible. Hemex Health is headquartered in Portland, Oregon, with an additional presence in Mumbai, India.

Instinct Science is an animal health technology company providing veterinary practice management software designed to help hospitals stay efficient, ensure patient safety, and capture every charge. Its platform supports veterinarians and hospital staff with workflow tools, and in January 2026 acquired ScribbleVet to advance intelligent veterinary practice management.

Invio is a Seattle-based startup that develops FDA-compliant, cloud-based software to automate clinical trial workflows, replacing traditional paper and manual monitoring processes. The company makes clinical trials safer and faster through enterprise software for remote and automated trial monitoring. Invio was selected as the first company out of Madrona Venture Labs' accelerator in 2018.

InVivo Biosystems is a biotechnology company headquartered in Eugene, Oregon, that delivers expertise and technology to accelerate therapeutic discovery. The company uses its proprietary platform to advance drug discovery for neurological, metabolic, and rare monogenic diseases.