Kodak's former medical-imaging business — X-ray film, computed/digital radiography, PACS. Sold by Eastman Kodak to Onex Corporation (private equity) in 2007; HQ Rochester, NY.

CleanFiber is a Buffalo, NY-based manufacturer of high-performance cellulose insulation made from recycled corrugated cardboard boxes and other clean fiber sources. The company operates a state-of-the-art production facility in Buffalo with annual capacity of over 3 million bags of insulation. CleanFiber's liquid-enhanced manufacturing process produces what it markets as the purest and best-performing cellulose insulation available.

Dimien was a Buffalo, NY-based battery and clean energy technology startup that originated in a University at Buffalo lab. The company developed advanced battery and chemical manufacturing solutions in the clean energy sector. In October 2024, Dimien was acquired by Pure Lithium, a Boston-based lithium metal battery firm, marking a milestone for the Western New York clean tech ecosystem.

Edenesque is a Buffalo, NY-based plant-based dairy startup that produces chef-crafted products including pistachio milk and oat milk blends designed for coffee and culinary use. The company relocated its headquarters to Buffalo following investment from Launch NY, which invested $175,000 in April 2024. Edenesque is a mission-driven brand focused on premium plant-based alternatives.

FoodNerd is a Buffalo, NY-based, woman-owned food startup producing organic, nutrient-dense snack puffs made from 100% fruits, vegetables, and sprouted seeds targeted at toddlers. The company closed a $7.5 million Series Seed round and, as of 2025, operates a 30,000 sq. ft. FDA-registered production facility in Clarence, NY.

Kredit Academy is a white-labeled credit card and financial education platform designed for financial institutions and brands, helping organizations deliver engaging, trackable financial education that drives community impact and measurable results. The company is headquartered in Buffalo, New York.

LenderLogix is a point-of-sale and borrower experience platform built for Encompass, the mortgage origination system, serving hundreds of lenders across the country. Founded in 2016 and headquartered in Buffalo, New York, the company was ranked among the fastest-growing companies in the 2023 University at Buffalo Fast 46.

Offerwell is a Buffalo, NY-based real estate technology company that provides brokerages, MLSs, and agents a shared operating layer for listing, showing, offer, and follow-up workflows. The company graduated from UB's Cultivator program and raised pre-seed funding in 2023 to expand into Rochester and Syracuse markets.

Rarebird is a Buffalo, New York-based consumer beverage company that produces Px Coffee, billed as the first jitterless coffee. The product replaces caffeine with paraxanthine (Px) to deliver clean, steady energy and sharper focus without jitters, crashes, or sleep disruption. Rarebird received strategic investment from 43North, a Buffalo-based accelerator, and relocated its headquarters to Buffalo as part of that partnership.

Uncaged Innovations is a biomaterials company founded by Stephanie Downs and Dr. Xiaokun Wang that engineers premium, sustainable biomaterials and cruelty-free leather alternatives for global brands. The company combines natural science and technology to reimagine leather with sustainable biomaterials. While listed with an Albany, NY association, the company's LinkedIn lists New York as its headquarters.

Verivend is a Buffalo, NY-based investment management software platform that enables general partners and limited partners to raise and deploy private capital seamlessly. Founded in 2019, the company has processed over $2 billion in transactions and was acquired by iAltA in May 2025.

The Rochester company that built Xerox PARC — birthplace of the GUI, the mouse, Ethernet, and the laser printer; the overlooked source of modern personal computing.