Neuros Medical is a privately held medical device company and maker of the Altius® Direct Electrical Nerve Stimulation System, an FDA-approved device designed to treat chronic post-amputation pain. The company is headquartered in Willoughby Hills, Ohio.

BIOHM is a Cleveland, OH-based microbiome company that develops targeted probiotic supplements and gut health products combining good bacteria, good fungi, and digestive enzymes designed to break down digestive plaque. The company, also known as Biohm Technologies, leverages an extensive microbiome dataset to develop both consumer and B2B solutions, and unveiled a renewed brand identity focused on B2B in 2024.

Zuga Medical is a Chagrin Falls, Ohio-based medical device company and global leader in digital dentistry technology, manufacturing dental implant systems known for high quality and ease of use. Founded in 2007, the company is FDA-registered and operates facilities in the Cleveland, Ohio area.

Centerline Biomedical is a Cleveland, Ohio medical device company and spinoff of Cleveland Clinic that develops FDA-cleared surgical navigation technology to reduce radiation exposure and improve accuracy in endovascular procedures. Its flagship Intra-Operative platform provides real-time navigation guidance for vascular surgeons.

Cleveland Diagnostics is a Cleveland, Ohio-based cancer biotechnology company focused on improving cancer detection decisions. It offers the IsoPSA test, a novel and more accurate diagnostic for early detection of cancer and risk of high-grade disease.

GenomOncology is a Cleveland, Ohio-based precision oncology software company that provides the healthcare community with data-driven insights and software solutions to improve cancer care. Its platform supports genomic data analysis and clinical decision-making for oncology teams.

Lazurite is a medical device company headquartered in Cleveland, OH (formerly known as Indago) that developed the ArthroFree wireless camera system for arthroscopy. The company has raised more than $18 million in private capital and is backed in part by University Hospitals Ventures.

SPR Therapeutics is a privately held medical device company headquartered in Cleveland, Ohio, providing patients with a non-opioid, minimally invasive pain treatment option. The company employs nearly 100 people locally and more than 300 nationwide.