Sirnaomics is a clinical-stage RNA therapeutics biopharmaceutical company headquartered in Gaithersburg, Maryland, founded in 2007 and listed on the Hong Kong Stock Exchange (2257.HK). The company focuses on the discovery and development of innovative RNA-targeted drugs and was the first to achieve positive Phase IIb clinical outcomes in oncology RNA therapeutics.

AI-driven Amazon/Walmart PPC and DSP advertising automation. Founded 2018 by Nadine Schoepper, Max Hofmann, Dominik Thuesing (Darmstadt Germany). 45 staff, 1,500+ customers in 43 countries, $300M+ ad spend managed, $3B GMV influenced. Acquired by Worldeye Technologies May 2025.

AI/ML platform for defense and national security applications. Winchester VA. DataTribe portfolio.

Acclaim Technical Services (ATS) — language and intelligence-analysis services and mission IT for the U.S. intelligence community. Founded 2000; employee-owned (ESOP since 2013). Backed by Blue Delta Capital; acquisitive (Axis of Engineering, Global Consulting Services, Entegra Systems, OASIC Engineering, Alder Technology).

Materials science background from IQT. Does AI work. Small firm.

Human-centered digital services for federal and state government (product, engineering, design, cloud, modernization). Founded by core members of the HealthCare.gov rescue team; work includes Medicare Plan Finder and VA. ~500 employees. Backed by Blue Delta Capital; privately held.

Bacteriophage therapy for drug-resistant infections (PhageBank). I-270 corridor.

Adial Pharmaceuticals is a Charlottesville, Virginia-based clinical-stage biopharmaceutical company focused on developing treatments for alcohol use disorder and other addictions. Its lead therapeutic candidate targets the serotonin-3 receptor to reduce alcohol consumption. The company is publicly traded on the Nasdaq under the ticker ADIL.

Cloud-based UEBA and managed security platform for mid-market. Washington DC. MACH37 alumni (Fall 2016 cohort). Founders: Robert Johnston + Timothy Evans. Acquired by N-able November 2024.

Advaray (formerly BrachyFoam, Inc.) was an early-stage medical device company based in Charlottesville, Virginia developing devices for cancer therapy applications. The company was a University of Virginia Licensing & Ventures Group startup that was acquired by cancer therapy leader CQ Medical in October 2023.

Flight instruction (private, instrument, commercial, multi-engine, tailwheel, CFI) and aircraft rental; based in the main terminal at Leesburg Executive Airport (KJYO), 1001 Sycolin Rd SE Suite 1B, Leesburg, VA.

Applied Information Sciences (AIS) — cloud transformation, AI, application modernization and secure data solutions for the U.S. federal government and Fortune 1000. Employee-owned; Microsoft partner. Backed by Blue Delta Capital.

Benefits administration. Clarke Wallace (fmr IQT VP) is VP Strategic Account Executive.

Amida Technology Solutions — enterprise data management, interoperability and security for cybersecurity, healthcare and public-sector clients; major Department of Veterans Affairs partner. Founded 2013 by Peter L. Levin with Dmitry Kachaev and Matt McCall.

AMP3D is a Charlottesville, Virginia-based healthcare analytics company that provides predictive analytics monitoring via its proprietary SaaS platform CoMET. The platform processes big data from clinical settings to predict potentially catastrophic events such as emergent intubation and hemorrhage, enabling earlier intervention. AMP3D was acquired by Nihon Kohden in 2021.

Digital ABA therapy platform for children with autism. HQ Richmond, VA. Blue Heron Capital active portfolio company.

Antithesis is a Vienna, Virginia-based autonomous software testing company founded in 2018 that de-risks agentic development of critical systems. Its platform runs a complete system, exhaustively analyzes its behavior, and exposes bugs — and has gained significant traction in the fintech sector.

CAR-T cell therapy (ddCAR / anito-cel for multiple myeloma). I-270 corridor.

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