TPA Stream is a Cleveland, Ohio-based software company founded in 2014 that helps benefits and medical third-party administrators (TPAs) automate claims collection and produce cleaner employer invoices. Its platform turns disconnected billing and administrative data into streamlined operations for TPA teams, brokers, and employers.

orthobrain is a Cleveland, Ohio-based dental practice growth system that empowers general dentists to integrate and deliver orthodontic services with confidence. It provides a combination of support, technology, and treatment systems designed to make orthodontics easy and profitable for general dental practices.

SPR Therapeutics is a privately held medical device company headquartered in Cleveland, Ohio, providing patients with a non-opioid, minimally invasive pain treatment option. The company employs nearly 100 people locally and more than 300 nationwide.

Axuall is a workforce intelligence company built on a national, real-time practitioner data network, serving the healthcare industry. Headquartered at 707 Huron Rd E in Cleveland, Ohio, the company partners with leading health systems, including Cleveland Clinic, to advance provider data integrity.

Centerline Biomedical is a Cleveland, Ohio medical device company and spinoff of Cleveland Clinic that develops FDA-cleared surgical navigation technology to reduce radiation exposure and improve accuracy in endovascular procedures. Its flagship Intra-Operative platform provides real-time navigation guidance for vascular surgeons.

Cleveland Diagnostics is a Cleveland, Ohio-based cancer biotechnology company focused on improving cancer detection decisions. It offers the IsoPSA test, a novel and more accurate diagnostic for early detection of cancer and risk of high-grade disease.

GenomOncology is a Cleveland, Ohio-based precision oncology software company that provides the healthcare community with data-driven insights and software solutions to improve cancer care. Its platform supports genomic data analysis and clinical decision-making for oncology teams.

Lazurite is a medical device company headquartered in Cleveland, OH (formerly known as Indago) that developed the ArthroFree wireless camera system for arthroscopy. The company has raised more than $18 million in private capital and is backed in part by University Hospitals Ventures.

Neuros Medical is a privately held medical device company and maker of the Altius® Direct Electrical Nerve Stimulation System, an FDA-approved device designed to treat chronic post-amputation pain. The company is headquartered in Willoughby Hills, Ohio.

Zuga Medical is a Chagrin Falls, Ohio-based medical device company and global leader in digital dentistry technology, manufacturing dental implant systems known for high quality and ease of use. Founded in 2007, the company is FDA-registered and operates facilities in the Cleveland, Ohio area.