Augment Therapy is an award-winning digital health company headquartered in Cleveland, Ohio that creates augmented reality rehabilitation exercises and gamified wellness experiences for people of all ages and ability levels. The company raised $2.7 million in funding and was selected as a 2022 Unity for Humanity award recipient.

Axuall is a workforce intelligence company built on a national, real-time practitioner data network, serving the healthcare industry. Headquartered at 707 Huron Rd E in Cleveland, Ohio, the company partners with leading health systems, including Cleveland Clinic, to advance provider data integrity.

BIOHM is a Cleveland, OH-based microbiome company that develops targeted probiotic supplements and gut health products combining good bacteria, good fungi, and digestive enzymes designed to break down digestive plaque. The company, also known as Biohm Technologies, leverages an extensive microbiome dataset to develop both consumer and B2B solutions, and unveiled a renewed brand identity focused on

BIOHM Health is a Cleveland, OH-based gut health company offering probiotic supplements, super greens powders, and colon cleanse products designed to support the microbiome. Its parent entity, Biohm Technologies, has pivoted toward B2B solutions leveraging the company's extensive microbiome dataset.

Bloomfilter is a Cleveland, OH-based process mining company focused on the software development lifecycle. Its platform helps product teams align people and intelligent systems to ship faster and reduce waste by providing visibility into engineering workflows. Bloomfilter was founded in 2022.

Private research university in Cleveland — medicine, engineering, sciences.

Centerline Biomedical is a Cleveland, Ohio medical device company and spinoff of Cleveland Clinic that develops FDA-cleared surgical navigation technology to reduce radiation exposure and improve accuracy in endovascular procedures. Its flagship Intra-Operative platform provides real-time navigation guidance for vascular surgeons.

Cleveland Diagnostics is a Cleveland, Ohio-based cancer biotechnology company focused on improving cancer detection decisions. It offers the IsoPSA test, a novel and more accurate diagnostic for early detection of cancer and risk of high-grade disease.

GenomOncology is a Cleveland, Ohio-based precision oncology software company that provides the healthcare community with data-driven insights and software solutions to improve cancer care. Its platform supports genomic data analysis and clinical decision-making for oncology teams.

Hyland is a privately held enterprise content services and management company headquartered in Westlake, Ohio. The company provides software solutions — including its flagship OnBase platform — for capture, content management, and business process automation to organizations worldwide, and employs between 1,000 and 5,000 people.

Lazurite is a medical device company headquartered in Cleveland, OH (formerly known as Indago) that developed the ArthroFree wireless camera system for arthroscopy. The company has raised more than $18 million in private capital and is backed in part by University Hospitals Ventures.

MakerGear is a Beachwood, Ohio-based company that designs, engineers, and manufactures high-quality desktop 3D printers. Founded in 2009, it is a privately held company with 11–50 employees, known for building machines with leading-quality components for professional and prosumer use.

MediView XR is a Cleveland, Ohio-based med-tech company pioneering the use of augmented reality (AR), mixed reality, and spatial computing to transform medical imaging and surgical guidance. The company collaborates with leading technology partners, academic institutions, and hospitals including the Cleveland Clinic to drive innovation in medical AR. MediView leverages remote connectivity and spat

Neuros Medical is a privately held medical device company and maker of the Altius® Direct Electrical Nerve Stimulation System, an FDA-approved device designed to treat chronic post-amputation pain. The company is headquartered in Willoughby Hills, Ohio.

OnStation is a Cleveland, Ohio-based B2B software company offering a digital stationing platform for the road construction industry. Its tools support inspectors, contractors, and DOT teams in locating and managing project data from bidding through closeout.

orthobrain is a Cleveland, Ohio-based dental practice growth system that empowers general dentists to integrate and deliver orthodontic services with confidence. It provides a combination of support, technology, and treatment systems designed to make orthodontics easy and profitable for general dental practices.

Progressive is a major U.S. insurance company headquartered in Mayfield Village, Ohio, offering auto, home, and other personal and commercial insurance products. Its corporate campus is located at the southwest corner of I-271 and Wilson Mills Road in Mayfield Village, a Cleveland suburb.

Sherwin-Williams is a global manufacturer, developer, distributor, and retailer of paints, coatings, and related products headquartered in Cleveland, Ohio. Founded in 1866 by Henry Sherwin and Edward Williams, the company operates thousands of retail locations and serves both professional contractors and DIY customers worldwide.

SPR Therapeutics is a privately held medical device company headquartered in Cleveland, Ohio, providing patients with a non-opioid, minimally invasive pain treatment option. The company employs nearly 100 people locally and more than 300 nationwide.

Tooling U-SME is a Cleveland, Ohio-based workforce development organization that delivers competency-based learning and training solutions to the manufacturing industry. It works with thousands of companies to empower manufacturing workers and create pathways to career advancement.