Puerto Rico's largest private university system, founded in 1949, serving roughly 40,000 students across its Universidad del Turabo, Universidad Metropolitana and Universidad del Este campuses plus an online AGM Virtual Campus.

Private, nonprofit Hispanic-serving Christian university system founded in 1912 with nine campuses across Puerto Rico; its Metropolitan Campus in San Juan is its largest academic unit, enrolling over 5,000 students.

Public university system founded in 1903; its Rio Piedras campus is the oldest and largest higher-education institution in the Caribbean, with roughly 22,000 undergraduate and 3,700 graduate students across eleven campuses system-wide.