General Dynamics Information Technology -- defense IT/cyber contractor; opened a dedicated cyber facility at Port San Antonio explicitly to support 16th Air Force and JBSA-Lackland. Global HQ is Falls Church, VA; this is their San Antonio cyber-mission presence.

Petroleum refining company, largest refiner in the U.S. with 14 refineries; HQ in San Antonio.

Nonprofit holding company operating South Texas Blood & Tissue Center, QualTex Laboratories, and GenCure (cell-therapy biomanufacturing, Texas Cord Blood Bank).

Numbered Air Force running cyber warfare, electronic warfare, information operations, and ISR for the U.S. Air Force; headquartered at Joint Base San Antonio-Lackland.

Darkhive develops US-produced open autonomous robotics and drone systems for the defense and public safety communities, founded in 2021. In April 2026 the Pentagon awarded the company a $49.7 million contract.

Privately held grocery retail chain, 435+ stores across Texas/Mexico; HQ at the historic Arsenal site in San Antonio.

Financial services/insurance company; HQ on a 286-300 acre San Antonio campus with ~17,000 local employees; 50th anniversary on this campus in 2026.

Network security pioneer -- built NetRanger, an early intrusion detection system; acquired by Cisco Systems in 1998 (~$124M), becoming the basis of Cisco's security business. San Antonio's founding cyber-security company.