AirSeal CardioVascular Inc. is a medical diagnostics company headquartered at 4340 Duncan Ave, St. Louis, MO, focused on transforming the detection and management of peripheral arterial disease (PAD). The company was founded in 2022 and is privately held.

Alfa-Ruby is a protein innovation company headquartered in St. Louis, MO that unlocks the full potential of alfalfa to produce high-performance plant protein. The company addresses the need for plant protein that does not compromise on taste, nutrition, or functionality compared to animal proteins. Founded in 2025, it is a privately held startup.

Allumin8 is a St. Louis-based medical device startup that develops FDA-cleared spinal fixation systems designed to reduce reoperation rates in spine surgery. The company's proprietary porous implant design allows surgeons to diagnose, treat, and accelerate healing directly through the implant. Allumin8 received FDA clearance in November 2025, becoming the first medical device company to achieve th

Archetype is a platform that transforms space planning and procurement for designers and developers, auto-generating on-spec layouts and curated product selections. The company is based in St. Louis, Missouri and is a recipient of an Arch Grants award.

ASL Aspire is an EdTech company based in St. Louis, MO that teaches STEM to K-12 deaf students and their teachers through American Sign Language. Its platform includes interactive arcade games, guided videos, practice modules, and quizzes to make learning STEM vocabulary in ASL engaging. The company has been recognized with a Global Impact Award from the Skandalaris Center at Washington University

Astrapi is a St. Louis, MO-based communications technology company and world leader in nonstationary spectrum technology using spiral-based, non-periodic signal modulation. Its approach boosts spectral efficiency and provides robust signal protection for radio systems. Astrapi positions its spiral modulation as a game-changing advancement in wireless communications.

Balto is a St. Louis, MO-based contact center AI software company, founded in 2017, offering real-time agent guidance, automated quality assurance, business insights, coaching, and call summarization. Its platform is designed to help contact center agents perform better during live calls and improve overall team performance.

St. Louis agricultural-science division (the former Monsanto) — global crop science.

BenefitsBoost is a St. Louis, MO-based company that is revolutionizing the Social Security disability benefits process by making disability benefits applications faster and more accessible. The company serves disability advocacy groups and individuals, providing tools to streamline the benefits application experience.

Benson Hill was an agriculture technology company founded in 2012 and headquartered in St. Louis, Missouri, focused on sustainable food innovation using crop biology. The company filed for Chapter 11 bankruptcy protection in March 2025, with its assets and work subsequently picked up by Confluence Genetics.

Boat Planet is a St. Louis, MO-based web platform founded in 2018 where boat owners can find, compare, and book trusted and reviewed marine service professionals. The company is headquartered at 4220 Duncan Avenue, Suite 201 in Saint Louis and operates as a small privately held firm connecting boat owners with vetted marine pros.

Bold Stone Creamery is a St. Louis-based startup developing a line of adult-focused ice cream flavors targeted at sales in St. Louis stadium venues. The company was selected as part of Arch Grants' 2024 annual cohort, receiving between $75,000 and $100,000 in seed funding from the St. Louis nonprofit. As a condition of the grant, Bold Stone Creamery relocated to St. Louis to grow its business in t

Centene Corporation is a leading managed care organization headquartered in St. Louis, Missouri, providing access to high-quality healthcare solutions for families and individuals. The company operates as a government-sponsored managed care plan across multiple states. Its corporate headquarters is located at 7700 Forsyth Boulevard, St. Louis, MO 63105.

CoverCress is a St. Louis, Missouri agricultural biotechnology company that has developed a new cover crop — derived from field pennycress — that serves as both a sustainable cover crop and a cash crop for farmers, producing oil for renewable fuel and meal for animal feed.

Dad's Cookie Co. is a St. Louis, Missouri bakery that has been baking its original Scotch Oatmeal cookies since 1927. Cookies are baked daily and shipped free across the U.S. In 2024, a trio of brothers acquired the company, continuing its long-running south St. Louis tradition.

St. Louis independent plant-science research institute — anchor of its agtech cluster.

Geneoscopy is a St. Louis, Missouri life sciences company developing non-invasive RNA-based diagnostic tests to help prevent, detect, and monitor gastrointestinal diseases including colorectal cancer.

Kultevat Inc. is a St. Louis, Missouri biotechnology company that combines plant breeding and green process engineering to produce specialty natural rubber from Kazakh Dandelion (Taraxacum kok-saghyz). The company is located at the Helix Center in the 39 North innovation district.

MediBeacon is a St. Louis, Missouri-based medical technology company focused on advancing fluorescent tracer agents and their transdermal detection to help improve patient care, particularly in kidney function monitoring.

nCase Technologies is a St. Louis, MO-based company that designs discreet, durable, and convenient carrying cases for lifesaving emergency medicines, with a focus on Naloxone (Narcan) carry cases. Headquartered at 4555 Forest Park Ave. in St. Louis, the company's mission is to remove practical barriers to carrying opioid overdose reversal medication. nCase Tech is a portfolio company of Arch Grant