West Bancorporation is the publicly traded (Nasdaq: WTBA) holding company for West Bank, a community bank headquartered in West Des Moines, Iowa serving central Iowa and the Twin Cities.

Global agriscience business center in Johnston, Iowa (corporate HQ is Indianapolis) -- seed, crop protection, and digital agriculture.

Nearly 3.9 million square feet of hyperscale data center space in West Des Moines, with more planned, drawn by cheap power and available land.

Athene Holding is a retirement-services and fixed annuity company (subsidiary of Apollo Global Management) whose U.S. corporate headquarters is a 1,200+ employee campus at 7700 Mills Civic Parkway in West Des Moines, Iowa.

Casey's General Stores (Nasdaq: CASY) operates more than 2,900 convenience stores with in-store pizza kitchens across the Midwest, headquartered in Ankeny, Iowa.

Property and casualty insurance company headquartered in Des Moines.

Fareway Stores is an employee-owned Midwest grocery chain headquartered in Boone, Iowa, operating more than 130 stores across Iowa and neighboring states.

Farm Bureau-affiliated insurance and financial services company headquartered in West Des Moines.

Kum & Go is a privately held, family-owned convenience store chain founded in 1959 and headquartered in West Des Moines, Iowa, operating several hundred stores across the Midwest.

MidAmerican Energy is an Iowa electric and natural gas utility headquartered in Des Moines, a Berkshire Hathaway Energy subsidiary, and one of the largest owners of wind generation among U.S. regulated utilities.

Oculus VR was a virtual reality technology company founded in 2012 and acquired by Facebook (now Meta Platforms) in 2014. It developed the Oculus Rift headset and related VR hardware and software; the business was rebranded as Meta Reality Labs and its products now ship under the Meta Quest brand.

Fortune 500 financial services and insurance company headquartered in Des Moines.

UnityPoint Health is a nonprofit integrated health system headquartered in West Des Moines, Iowa, operating hospitals, clinics and home care services across Iowa, Illinois and Wisconsin.

Major health insurance provider headquartered in Des Moines, founded 1939.