723-acre specialty chemical plant in the Kanawha Valley, originally DuPont, in continuous operation for over 90 years.

Weirton, WV tinplate steel facility operated by Cleveland-Cliffs, the largest flat-rolled steel producer in North America (HQ Cleveland, OH); idled in 2024 after an adverse trade ruling, with a $150 million capital investment (including a $50 million WV forgivable loan) rebuilding the plant to reemploy roughly 600 USW-represented workers by 2026.

Private natural gas exploration/production and midstream firm operating in the Appalachian Basin.

Cross Lanes, WV-headquartered $6.3 billion bank holding company and parent of City National Bank of West Virginia, operating roughly 97 branches across West Virginia, Kentucky, Virginia, and Ohio. Nasdaq: CHCO.

Ravenswood, WV aluminum rolled-products plant — one of the largest in the world — operated by Constellium (global HQ Paris/Amsterdam, US HQ Baltimore); produces aerospace, defense, transportation, and industrial aluminum plate and sheet, employing more than 1,100 people.

R&D-focused Dow campus in the Kanawha Valley producing 500+ chemicals and plastics; technical staff down from a 1980s peak of 5,000+ to roughly 400-500 today.

Morgantown-headquartered off-price retail chain founded in 1961 by brothers James and Arthur Gabriel; operates roughly 131 Gabe's stores and 38 Old Time Pottery stores across 20 states from six distribution centers.

West Virginia's primary natural gas utility, founded 1984.

Fairmont-headquartered community bank holding company (MVB Bank) providing traditional banking alongside fintech and banking-as-a-service infrastructure for partner companies across the Mid-Atlantic. Nasdaq: MVBF.

Martinsburg, WV consumer-products manufacturing plant operated by Procter & Gamble (global HQ Cincinnati, OH); a $500 million facility that broke ground in 2015 producing Bounce dryer sheets and other household products, employing roughly 900 people.

Huntington-headquartered producer of high-performance nickel-based alloys and superalloys, the largest facility of its kind in the world devoted exclusively to nickel-alloy development and production; a subsidiary of Precision Castparts Corp. (Berkshire Hathaway).

Historic luxury resort that secretly housed a classified Cold War continuity-of-government bunker ("Project Greek Island", 1958-1992) built to shelter Congress, exposed by the Washington Post in 1992 and now a public bunker tour.

Toyota's only combined engine-and-transmission plant in North America; ~2,077 employees, over 1M units/year, with a $423M expansion for hybrid engine/transaxle assembly underway.

Charleston, WV-headquartered (dual HQ with Washington, DC) bank holding company operating roughly 240 branches across eight states and DC through its United Bank subsidiary; approximately $32 billion in assets. Nasdaq: UBSI.

Charleston-headquartered nonprofit hospital system of seven hospitals (~1,138 beds), established 1972 as CAMC and rebranded Vandalia Health; southern West Virginia's largest health-care system, its largest provider of uncompensated care, and a WVU School of Medicine teaching site.

Wheeling-headquartered bank holding company operating WesBanco Bank branches across West Virginia, Ohio, Pennsylvania, Kentucky, Indiana, and Virginia. Nasdaq: WSBC.

Morgantown-headquartered nonprofit health system anchored by J.W. Ruby Memorial Hospital, operating 25 hospitals across West Virginia, western Maryland, eastern Ohio, and southwestern Pennsylvania. West Virginia's largest private employer, with more than 35,000 employees and over $7 billion in annual revenue.