Missouri State University is a public university in Springfield, Missouri.

Southeast Missouri State University is a public university in Cape Girardeau, Missouri.

Lincoln University is the nation's first degree-granting Historically Black College and University (HBCU), offering more than 35 undergraduate and four graduate degree programs to a diverse student body of over 2,200 students. The university provides higher education across disciplines including business, sciences, humanities, and health services, and competes in NCAA Division II athletics with 11 varsity sports teams.

Lincoln University of Missouri is a historically black college and university founded in 1866 that offers more than 75 undergraduate and graduate degree programs through schools and departments including nursing, education, business, agriculture, sciences, humanities, and social sciences. The university also operates the Health and Security Sciences Institute, which provides healthcare education, public safety training, and workforce development programs to the Missouri and Midwest regions.