Claflin University is a private historically Black university (HBCU) located in South Carolina that offers undergraduate, graduate, professional, and online degree programs across disciplines including business, education, and nursing. The institution serves approximately 1,900 students and provides both traditional classroom-based and distance learning educational opportunities.

The College of Charleston is a public liberal arts university in Charleston, South Carolina.

Clemson University is a public land-grant research university in Clemson, South Carolina.

Charleston Southern University is a private Baptist university in Charleston, South Carolina.

Coastal Carolina University is a public university in Conway, South Carolina.

Denmark Technical College is a technical and community college that offers associate degree programs, workforce development training, and continuing education courses in fields including healthcare, industrial trades, culinary arts, and professional skills certifications. The institution provides tuition assistance programs and serves students seeking career training and technical education.

Furman University is a private liberal arts university in Greenville, South Carolina.

Presbyterian College is a private liberal arts college in Clinton, South Carolina.

South Carolina State University is a historically Black university founded in 1896 that offers over 40 undergraduate and graduate degree programs across engineering, business, education, agriculture, arts, and sciences. The university serves approximately 3,000 students and reports that 95% of its graduates obtain employment or advance to further education.

The Citadel is a public senior military college in Charleston, South Carolina.

The University of South Carolina is a public research university offering more than 350 bachelor's, master's, and doctoral degree programs across 15 colleges and schools. The institution provides academic and professional education in various disciplines, along with career-enhancing certificates and specialties.

Voorhees University is a historically Black university in Denmark, South Carolina, founded in 1897 by Elizabeth Evelyn Wright.

Winthrop University is a public university in Rock Hill, South Carolina.

Wofford College is a private liberal arts college in Spartanburg, South Carolina.